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Byrne and Winfrey as Skloot and Deborah Watch the full episode of The Jess Cagle Interview: Oprah Winfrey, streaming now on People/Entertainment Weekly Network (PEN). Go to PEOPLE.com/PEN, or download the app for Apple TV, Roku, Amazon Fire TV, Xumo, Chromecast, Xfinity, iOS and Android devices. The movie, airing April 22, explores the familys hardships after finding out about the existence of the cells – and their thwarted attempts to gather more information. And though Skloot – played by Rose Byrne in the movie – originally set out to tell Lacks tale, the author quickly realized the story went far beyond the woman behind the HeLa cells when she talked to Lacks daughter Deborah for the first time in 1999. To me, it was not only about the woman, but what that does to a family, Skloot tells PEOPLE. Deborah and I were both driven by this same obsessive passion to just answer these questions: Who was she? What happened? What can be done to make it so it doesnt happen again? Although Deborah and Skloot shared this common goal, it took years for the second-youngest Lacks child to trust her. The family had gone through years of alleged mistreatment from medical professionals and were burned by people who had tried taking advantage of their connection to the famous HeLa cells. Skloot had to overcome these insecurities and show Deborah she could be trusted with her mothers story.

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